Ellen Makkai writing in WorldNetDaily discusses sex-change surgery and looks at continuing disorientation some transsexuals feel post-operation. The attempt to feel the "same on the inside as on the outside" doesn't always end on a happy note. In fact a long-term follow-up report on adult transsexuals treated at Johns Hopkins revealed that none of the post-operatives showed measurable improvement in their lives.
And here's a tragic story of David Reimer who was "a boy, then a girl and then a boy again." Born a boy, David was raised a girl after a botched circumcision at 8 months. After discovering his true identity at 11, he grew up and struggled to live as a man, which ended tragically last year in May 2004. He was 38 years. David's traumatic life story was first told by John Colapinto in a Rolling Stone article, and subsequently in the book, As Nature Made Him: The Boy Who Was Raised As A Girl before his suicide.
Natalie James' story about this medical tragedy and David's recollection of life as a girl is found here.